The project aims to technically and scientifically support the development of aquaculture production of pirarucu (Arapaima gigas), with new technologies in the areas of nutrition and health. The physiological mechanisms for the validation of the use of immunostimulating products and probiotics that act as prophylactics for the cultivation of fingerlings and juveniles of pirarucu will be the basis of the study. The innovations obtained will be transferred to the productive sector, establishing a protocol of Good Management Practices (GMPs) to maintain the well-being of these species. In addition to reducing the environmental impact of aquaculture through sustainable diets.