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Phenotypic divergence between broiler and layer chicken lines is regulated at the molecular level during development. Authorship: CONTRICIANI, R. E.; GRADE, C. V. C.; LEITE, I. B.; VEIGA, F. C. da; LEDUR, M. C.; REVERTER, A.; ALEXANDRE, P. A.; CESAR, A. S. M.; COUTINHO, L. L.; ALVARES, L. E. Abstract Background: Understanding the molecular underpinnings of phenotypic variations is critical for enhancing poultry breeding programs. The Brazilian broiler (TT) and laying hen (CC) lines exhibi... ... Repository: BDPA Publication year: 2024
Integration of different omics layers with SNP-SNP interaction networks associated with methane emission in nelore cattle. Authorship: CARDOSO, T. F.; BRUSCADIN, J. J.; DINIZ, W. J. da S.; BANERJEE, P.; AFONSO, J.; ANDRADE, B. G. N. B; MALHEIROS, J. M.; ZERLOTINI NETO, A.; VIEIRA, D. da S.; FERNANDES, A. C.; CESAR, A. S. M.; MOURÃO, G. B.; COUTINHO, L. L.; REGITANO, L. C. de A. Here, we reported the impact of these interactions in other omics layers (i.e., microorganisms and metabolites profile in the rumen and stool, and mRNA and miRNA expression in the rumen tissue). Repository: BDPA Publication year: 2022
Integrative analysis between genome-wide association study and expression quantitative trait Loci reveals bovine muscle gene expression regulatory polymorphisms associated with intramuscular fat and backfat thickness. Authorship: VIGNATO, B. S.; CESAR, A. S. M.; AFONSO, J.; MOREIRA, G. C. M.; POLETI, M. D.; PETRINI, J.; GARCIA, I. S.; CLEMENTE, L. G.; MOURÃO, G. B.; REGITANO, L. C. de A.; COUTINHO, L. L. Understanding the architecture of gene expression is fundamental to unravel the molecular mechanisms regulating complex traits in bovine, such as intramuscular fat content (IMF) and backfat thickness... ... Repository: BDPA Publication year: 2022
Multi-omic data integration for the study of production, carcass, and meat quality traits in Nellore cattle. Authorship: NOVAIS, F. J. DE; YU, H.; CESAR, A. S. M.; MOMEN, M.; POLETI, M. D.; PETRY, B.; MOURÃO, G. B.; REGITANO, L. C. de A.; MOROTA, G.; COUTINHO, L. L. Data integration using hierarchical analysis based on the central dogma or common pathway enrichment analysis may not reveal non-obvious relationships among omic data. Here, we applied factor analysis... ... Repository: BDPA Publication year: 2022
Differential gene expression associated with soybean oil level in the diet of pigs. Authorship: FINALLI, S. L.; SILVA, B. P. M. DA; GOMES, J. D.; ALMEIDA, V. V. DE; FREITAS, F. A. O.; MOREIRA, G. C. M.; VIGNATO, B. S.; AFONSO, J.; REECY, J.; KOLTES, J.; KOLTES, D.; REGITANO, L. C. de A.; GARRICK, D. J.; BALIEIRO, J. C. DE C.; MEIRA, A. N.; FREITAS, L.; COUTINHO, L. L.; FUKUMASU, H.; MOURÃO, G. B.; ALENCAR, S. M. DE; LUCHIARI FILHO, A.; CESAR, A. S. M. The aim of this study was to identify the differentially expressed genes (DEG) from the skeletal muscle and liver samples of animal models for metabolic diseases in humans. To perform the study, the f... ... Repository: BDPA Publication year: 2022
Effect of dietary soybean oil inclusion on liver-related transcription factors in a pig model for metabolic diseases. Authorship: FANALLI, S. L.; SILVA, B. P. M. DA; GOMES, J. D.; CICONELLO, F. N.; ALMEIDA, V. V. DE; FREITAS, F. A. O.; MOREIRA, G. C. M.; VIGNATO, B. S.; AFONSO, J.; REECY, J.; KOLTES, J.; KOLTES, D.; REGITANO, L. C. de A.; BAILEIRO, J. C. DE C.; FREITAS, L.; COUTINHO, L. L.; FUKUMASU, H.; ALENCAR, S. M. DE; LUCHIARI FILHO, A.; CESAR, A. S. M. Dietary fatty acids (FA) are components of the lipids, which contribute to membrane structure, energy input, and biological functions related to cellular signaling and transcriptome regulation. Howeve... ... Repository: BDPA Publication year: 2022
Different dietary oil sources alter the transcription profile of the TNF-a pathway in porcine muscle. Authorship: FANALLI, S. L.; GOMES, J. D.; CAMPOS, D.; SILVA, B. P. M. DA; MEIRA, A. N.; REGITANO, L. C. de A.; ALMEIDA, V. V. DE; GARRICK, D.; COUTINHO, L. L.; CESAR, A. S. M. Inflammatory processes are dependent on lipid and protein mediators, such as fatty acids (FAs) which modulate the release of cytokines from macrophages. Repository: BDPA Publication year: 2021
Multi-omics approach reveals miR-SNPs affecting muscle fatty acids profile in Nelore cattle. Authorship: CARDOSO, T. F.; COUTINHO, L. L.; BRUSCADIN, J. J.; DINIZ, W. J. da S.; PETRINI, J.; ANDRADE, B. G. N.; OLIVEIRA, P. S. N. de; POLETI, M. D.; CESAR, A. S. M.; SILVEIRA, J. C. DA; CHIARATTI, M. R.; ZERLOTINI NETO, A.; MOURÃO, G. B.; REGITANO, L. C. de A. MicroRNAs (miRNAs) are key regulators of gene expression, potentially affecting several biological processes, whose function can be altered by sequence variation. Hence, the integration of single nucl... ... Repository: BDPA Publication year: 2021
Genetic regulators of mineral amount in Nelore cattle muscle predicted by a new co-expression and regulatory impact factor approach. Authorship: AFONSO, J.; FORTES, M. R. S.; REVERTER, A.; DINIZ, W. J. da S.; CESAR, A. S. M.; LIMA, A. O. de; PETRINI, J.; SOUZA, M. de S.; COUTINHO, L. L.; MOURÃO, G. B.; ZERLOTINI NETO, A.; GROMBONI, C. F.; NOGUEIRA, A. R. A.; REGITANO, L. C. de A. Mineral contents in bovine muscle can affect meat quality, growth, health, and reproductive traits. To better understand the genetic basis of this phenotype in Nelore (Bos indicus) cattle, we analysed... ... Repository: BDPA Publication year: 2020
Allele-specific expression is widespread in Bos indicus muscle and affects meat quality candidate genes. Authorship: SOUZA, M. M. de; ZERLOTINI NETO, A.; ROCHA, M. I. P.; BRUSCADIN, J. J.; DINIZ, W. J. da S.; CARDOSO, T. F.; CESAR, A. S. M.; AFONSO, J.; ANDRADE, B. G. N.; MUDADU, M. de A.; MOKRY, F. B.; TIZIOTO, P. C.; OLIVEIRA, P. S. N. de; NICIURA, S. C. M.; COUTINHO, L. L.; REGITANO, L. C. de A. Differences between the expression of the two alleles of a gene are known as allele-specific expression (ASE), a common event in the transcriptome of mammals. Despite ASE being a source of phenotypic... ... Repository: BDPA Publication year: 2020

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