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Repressive epigenetic mechanisms, such as the H3K27me3 histone modification, were predicted to affect muscle gene expression and its mineral content in Nelore cattle. Authorship: AFONSO, J.; SHIM, W. J.; BODEN, M.; FORTES, M. R. S.; DINIZ, W. J. da S.; LIMA, A. O. de; ROCHA, M. I. P.; CARDOSO, T. F.; BRUSCADIN, J. J.; GROMBONI, C. F.; NOGUEIRA, A. R. A.; MOURÃO, G. B.; ZERLOTINI NETO, A.; COUTINHO, L. L.; REGITANO, L. C. de A. Abstract. Epigenetic repression has been linked to the regulation of different cell states. In this study, we focus on the influence of this repression, mainly by H3K27me3, over gene expression in mus... ... Repository: BDPA Publication year: 2023
Differential allelic expression and co-expression revealed oxidative stress-dependent proteolysis as a key regulator of nelore beef tenderness. Authorship: BRUSCADIN, J. J.; CARDOSO, T. F.; DINIZ, W. J. da S.; SOUZA, M. M. de; AFONSO, J.; VIEIRA, D. da S.; MALHEIROS, J.; ANDRADE, B. G.; PETRINI, J.; FERRAZ, J. B. S.; ZERLOTINI NETO, A.; MOURÃO, G.; COUTINHO, L. L. L; REGITANO, L. C. de A. These findings suggest the impact of cis-regulatory variants on both the gene expression and phenotypic variation of Nelore muscle. These results can guide the investigation of regulatory variants aff... ... Repository: BDPA Publication year: 2022
Integration of different omics layers with SNP-SNP interaction networks associated with methane emission in nelore cattle. Authorship: CARDOSO, T. F.; BRUSCADIN, J. J.; DINIZ, W. J. da S.; BANERJEE, P.; AFONSO, J.; ANDRADE, B. G. N. B; MALHEIROS, J. M.; ZERLOTINI NETO, A.; VIEIRA, D. da S.; FERNANDES, A. C.; CESAR, A. S. M.; MOURÃO, G. B.; COUTINHO, L. L.; REGITANO, L. C. de A. Here, we reported the impact of these interactions in other omics layers (i.e., microorganisms and metabolites profile in the rumen and stool, and mRNA and miRNA expression in the rumen tissue). Repository: BDPA Publication year: 2022
Differential allele-specific expression revealed functional variants and candidate genes related to meat quality traits in B. indicus muscle. Authorship: BRUSCADIN, J. J.; CARDOSO, T. F.; DINIZ, W. J. da S.; SOUZA, M. M. de; AFONSO, J.; VIEIRA, D.; MALHEIROS, J. M.; ANDRADE, B. G. N.; PETRINI, J.; FERRAZ, J. B. S.; ZERLOTINI NETO, A.; MOURÃO, G. B.; COUTINHO, L. L.; REGITANO, L. C. de A. Abstract: Traditional transcriptomics approaches have been used to identify candidate genes affecting economically important livestock traits. Regulatory variants affecting these traits, however, rema... ... Repository: BDPA Publication year: 2022
DNA methylation may affect beef tenderness through signal transduction in Bos indicus. Authorship: SOUZA, M. M. de; NICIURA, S. C. M.; ROCHA, M. I. P.; PAN, Z.; ZHOU, H.; BRUSCADIN, J. J.; DINIZ, W. J. da S.; AFONSO, J.; OLIVEIRA, P. S. N. de; MOURÃO, G. B.; ZERLOTINI NETO, A.; COUTINHO, L. L.; KOLTES, J. E.; REGITANO, L. C. de A. Abstract. Background:Beef tenderness is a complex trait of economic importance for the beef industry. Understanding the epigenetic mechanisms underlying this trait may help improve the accuracy of bre... ... Repository: BDPA Publication year: 2022
Multi-omics approach reveals miR-SNPs affecting muscle fatty acids profile in Nelore cattle. Authorship: CARDOSO, T. F.; COUTINHO, L. L.; BRUSCADIN, J. J.; DINIZ, W. J. da S.; PETRINI, J.; ANDRADE, B. G. N.; OLIVEIRA, P. S. N. de; POLETI, M. D.; CESAR, A. S. M.; SILVEIRA, J. C. DA; CHIARATTI, M. R.; ZERLOTINI NETO, A.; MOURÃO, G. B.; REGITANO, L. C. de A. MicroRNAs (miRNAs) are key regulators of gene expression, potentially affecting several biological processes, whose function can be altered by sequence variation. Hence, the integration of single nucl... ... Repository: BDPA Publication year: 2021
Muscle allele-specific expression QTLs may affect meat quality traits in Bos indicus. Authorship: BRUSCADIN, J. J.; SOUZA, M. M. de; OLIVEIRA, K. S. de; ROCHA, M. I. P.; AFONSO, J.; CARDOSO, T. F.; ZERLOTINI NETO, A.; COUTINHO, L. L.; NICIURA, S. C. M.; REGITANO, L. C. de A. Abstract. Single nucleotide polymorphisms (SNPs) located in transcript sequences showing allele-specific expression (ASE SNPs) were previously identified in the Longissimus thoracis muscle of a Nelore... ... Repository: BDPA Publication year: 2021
Allele-specific expression is widespread in Bos indicus muscle and affects meat quality candidate genes. Authorship: SOUZA, M. M. de; ZERLOTINI NETO, A.; ROCHA, M. I. P.; BRUSCADIN, J. J.; DINIZ, W. J. da S.; CARDOSO, T. F.; CESAR, A. S. M.; AFONSO, J.; ANDRADE, B. G. N.; MUDADU, M. de A.; MOKRY, F. B.; TIZIOTO, P. C.; OLIVEIRA, P. S. N. de; NICIURA, S. C. M.; COUTINHO, L. L.; REGITANO, L. C. de A. Differences between the expression of the two alleles of a gene are known as allele-specific expression (ASE), a common event in the transcriptome of mammals. Despite ASE being a source of phenotypic... ... Repository: BDPA Publication year: 2020
Associação entre variantes cis regulatórias do gene KCNJ11e características econômicas em bovinos Nelore. Authorship: OLIVEIRA, K. S. de; LIMA, A. O. de; AFONSO, J.; CARDOSO, T. F.; BRUSCADIN, J. J.; REGITANO, L. C. de A. Características de produção como eficiência alimentar e de qualidade da carne bovina são de suma importância para o agronegócio, agroindústria e consumidores. Assim, ferramentas biotecnológicas como a... ... Repository: BDPA Publication year: 2019

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